Description

Ethyl-D5-Malonic Acid is a deuterated derivative of malonic acid, specifically labeled with five deuterium atoms on the ethyl moiety. This isotopic labeling is critical for applications requiring high chemical stability and minimal background interference in spectroscopic analysis. It is an essential building block and analytical standard for researchers and manufacturers in the pharmaceutical and advanced materials sectors, particularly for drug metabolism studies and the development of deuterated active pharmaceutical ingredients (APIs).

Application

• Deuterated Pharmaceutical Intermediate: A key precursor in the synthesis of deuterium-labeled drugs, where the incorporation of deuterium can improve metabolic stability and pharmacokinetic profiles.
• Internal Standard for Mass Spectrometry: Used as a stable isotope-labeled internal standard in LC-MS and GC-MS for the accurate quantification of malonic acid and related compounds in complex biological matrices.
• NMR Spectroscopy Solvent & Reagent: Employed in Nuclear Magnetic Resonance (NMR) spectroscopy as a deuterated reagent or for creating deuterated environments to simplify spectral analysis.
• Organic Synthesis & Research Chemical: Serves as a specialized reagent in organic synthesis for introducing deuterium labels into target molecules for mechanistic and tracer studies.
• Material Science Research: Utilized in the development of novel deuterated polymers and organic electronic materials where isotopic purity affects material properties.

Basic Information

Product Name	Ethyl-D5-Malonic Acid
CAS No.	66311-22-6
Molecular Formula	C5H3D5O4
Molecular Weight	137.13 g/mol
Synonyms	Diethyl-D5-malonate-d5; Ethyl malonate-d5; Malonic acid, diethyl-d5 ester; Diethyl pentadeuteriomalonate; [2H5]-Diethyl malonate; Diethyl (2H5)malonate; Ethyl-D5 propanedioate; Deuterated diethyl malonate
EINECS	Contact for details

Quality Control

Our Ethyl-D5-Malonic Acid is produced under strict quality management protocols to ensure high isotopic and chemical purity, essential for sensitive research and manufacturing applications. Each batch is characterized by advanced analytical techniques including NMR, GC-MS, and HPLC to confirm deuterium incorporation and chemical identity. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to prevent absorption of atmospheric moisture, which can affect purity and stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 98.0%
Isotopic Enrichment (D5)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.