Description

(1R)-(+)-(1-Amino-2-Methylpropyl)Phosphonic Acid CAS NO 66254-56-6 is a chiral, non-proteinogenic amino acid analog featuring a phosphonic acid group, making it a valuable building block in medicinal chemistry and asymmetric synthesis. This compound is particularly significant for its role as a key intermediate in the development of enzyme inhibitors and biologically active molecules targeting metabolic pathways. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity chiral synthons for advanced R&D and production.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel drug candidates, particularly enzyme inhibitors and prodrugs.
• Agrochemical Research: Used in developing advanced herbicides, plant growth regulators, and other bioactive agrochemicals with specific stereochemical requirements.
• Biochemical Tool Compound: Serves as a substrate analog or inhibitor in enzymatic studies and metabolic pathway research.
• Ligand Synthesis: Employed in the preparation of chiral ligands for asymmetric catalysis and metal complexation.
• Peptidomimetics: Incorporated into peptide analogs to enhance stability, bioavailability, and biological activity.
• Material Science: Potential monomer or additive for creating functional polymers with specific chelating or bioactive properties.

Basic Information

Product Name	(1R)-(+)-(1-Amino-2-Methylpropyl)Phosphonic Acid
CAS No.	66254-56-6
Molecular Formula	C₄H₁₂NO₃P
Molecular Weight	153.12 g/mol
Synonyms	(R)-(+)-1-Amino-2-methylpropylphosphonic Acid; (1R)-1-Amino-2-methylpropylphosphonic Acid; D-1-Amino-2-methylpropylphosphonic Acid; (R)-1-Amino-2-methylpropylphosphonic Acid; (R)-Homoalanin-4-ylphosphonic Acid; (1R)-(+)-AMPAPh; Phosphonic acid, P-[(1R)-1-amino-2-methylpropyl]-
EINECS	Contact for details

Quality Control

Our (1R)-(+)-(1-Amino-2-Methylpropyl)Phosphonic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for research and industrial use. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.