Description

(1S)-(-)-(1-Amino-2-Methylpropyl)Phosphonic Acid CAS NO 66254-55-5 is a high-purity, single-enantiomer organophosphorus compound that serves as a critical chiral building block in advanced synthesis. Its primary value lies in its unique structural motif, combining an amino group and a phosphonic acid moiety on a chiral carbon backbone, enabling precise molecular interactions. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries who require enantiomerically pure intermediates for developing active ingredients, such as enzyme inhibitors and chiral ligands.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of novel drug candidates, particularly those targeting metabolic and bone-related disorders.
• Agrochemical Research: Used in developing enantiomerically pure herbicides and plant growth regulators with improved efficacy and environmental profiles.
• Catalyst & Ligand Synthesis: Serves as a starting material for creating sophisticated chiral phosphonate-based ligands used in asymmetric catalysis.
• Biochemical Probe Development: Employed in research to design and synthesize specific inhibitors for phosphonate-metabolizing enzymes.
• Coordination Chemistry: Acts as a chelating agent for metal ions, useful in material science and metal recovery processes.
• Peptidomimetics: Incorporated into peptide analogs to enhance stability and biological activity by mimicking phosphate groups.

Basic Information

Product Name	(1S)-(-)-(1-Amino-2-Methylpropyl)Phosphonic Acid
CAS No.	66254-55-5
Molecular Formula	C4H12NO3P
Molecular Weight	153.12 g/mol
Synonyms	(S)-1-Amino-2-methylpropylphosphonic Acid; (1S)-1-Amino-2-methylpropylphosphonic Acid; L-AMP; (-)-AMP; (S)-AMP; (S)-1-Amino-2-methylpropylphosphonate; Phosphonic acid, P-[(1S)-1-amino-2-methylpropyl]-; (S)-2-Amino-3-methylbutylphosphonic Acid
EINECS	Contact for details

Quality Control

Every batch of (1S)-(-)-(1-Amino-2-Methylpropyl)Phosphonic Acid is manufactured under a strict quality management system. We provide comprehensive analytical documentation to ensure identity, purity, and enantiomeric excess meet the rigorous standards required for research and commercial synthesis. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.