Description

2-(5-Chloro-Pyridin-2-Yl)-4H-Isoquinoline-1,3-Dione is a high-purity, heterocyclic organic compound featuring a fused isoquinoline-1,3-dione core linked to a chlorinated pyridine moiety. This molecular architecture makes it a valuable advanced pharmaceutical intermediate (API Intermediate) and a versatile building block for medicinal chemistry research. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of novel therapeutic agents, particularly those targeting central nervous system disorders.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of new drug candidates, especially for neurological and psychiatric applications.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the multi-step synthesis of complex target molecules for preclinical and clinical evaluation.
• Biochemical Tool Compound: Potential use in biochemical assays to study enzyme inhibition or receptor binding mechanisms.
• Fine Chemical Synthesis: Employed in the preparation of specialized dyes, pigments, or functional materials requiring its specific heterocyclic structure.

Basic Information

Product Name	2-(5-Chloro-Pyridin-2-Yl)-4H-Isoquinoline-1,3-Dione
CAS No.	66177-34-2
Molecular Formula	C₁₄H₇ClN₂O₂
Molecular Weight	270.67 g/mol
Synonyms	2-(5-Chloropyridin-2-yl)-1H-isoquinoline-1,3(2H,4H)-dione; 2-(5-Chloro-2-pyridinyl)-1,2-dihydro-4H-isoquinoline-1,3-dione; 5-Chloro-2-(1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-2-yl)pyridine; 2-(5-Chloro-2-pyridyl)-4H-isoquinoline-1,3-dione; 66177-34-2; 2-(5-Chloropyridin-2-yl)isoquinoline-1,3(2H,4H)-dione
EINECS	Contact for details

Quality Control

Our 2-(5-Chloro-Pyridin-2-Yl)-4H-Isoquinoline-1,3-Dione is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.