Description

Nicotinic-D4 Acid is a stable isotope-labeled analog of nicotinic acid (Vitamin B3), where four hydrogen atoms are replaced by deuterium. This high-purity compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy in analytical measurements. It is critically required by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in metabolic pathway studies, pharmacokinetic research, and the development of novel vitamin-based therapeutics.

Application

• Mass Spectrometry Internal Standard: Primary use as a deuterated internal standard for the precise quantification of nicotinic acid and its metabolites in biological matrices via LC-MS/MS and GC-MS.
• Pharmacokinetic & Drug Metabolism Studies (DMPK): Enables accurate tracking of absorption, distribution, metabolism, and excretion (ADME) of Vitamin B3 and related compounds.
• Clinical Research & Diagnostics: Used in developing and validating assays for measuring niacin status, NAD+ levels, and related biomarkers in human plasma and serum.
• Stable Isotope Labeling in Synthesis: Serves as a labeled building block for the synthesis of more complex deuterated molecules for research purposes.
• Nutritional Science Research: Facilitates advanced studies on Vitamin B3 bioavailability, turnover rates, and metabolic flux analysis.
• Quality Control in Pharmaceutical Manufacturing: Employed in analytical methods for the quality assurance of niacin-containing pharmaceutical formulations.

Basic Information

Product Name	Nicotinic-D4 Acid
CAS No.	66148-15-0
Molecular Formula	C6HD4NO2
Molecular Weight	127.12 g/mol (for C6HD4NO2)
Synonyms	Pyridine-3-carboxylic-2,4,5,6-d4 acid; Deuterated Nicotinic Acid; Nicotinic Acid-d4; 3-Carboxy-d4-pyridine; Vitamin B3-d4; Niacin-d4; 2,4,5,6-Tetradeuteronicotinic acid; Pyridine-d4-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our Nicotinic-D4 Acid CAS NO 66148-15-0 is manufactured under strict quality systems. Each batch is characterized by advanced spectroscopic methods (NMR, IR) and analyzed for isotopic purity and chemical purity by HPLC and/or GC-MS. We provide comprehensive Certificates of Analysis (COA) detailing assay, isotopic enrichment (typically >98 atom % D), and impurity profiles. Our quality commitment ensures consistency and reliability for your most sensitive analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The product is light-sensitive and should be handled accordingly to maintain stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 98% (by HPLC)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.