Description

n-(2,2,2-Trichloroethoxycarbonyloxy)Succinimide is a specialized active ester reagent widely used in organic synthesis and peptide chemistry. Its primary value lies in its role as a versatile coupling agent and protecting group activator, facilitating efficient and selective chemical transformations. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable and consistent building blocks for complex molecule synthesis.

Application

• Peptide Synthesis: Acts as an efficient coupling reagent for the formation of peptide bonds under mild conditions.
• Carbohydrate Chemistry: Used in the activation of carboxylic acids for glycosylation and other sugar derivatization reactions.
• Pharmaceutical Intermediates: Serves as a key reagent in the synthesis of active pharmaceutical ingredients (APIs) and complex drug candidates.
• Protecting Group Chemistry: Employed for the introduction and manipulation of the 2,2,2-trichloroethoxycarbonyl (Troc) protecting group for amines and alcohols.
• Bioconjugation: Facilitates the labeling and cross-linking of biomolecules for diagnostic and research applications.
• Polymer Science: Used in the synthesis of functionalized polymers and dendrimers with precise terminal groups.

Basic Information

Product Name	n-(2,2,2-Trichloroethoxycarbonyloxy)Succinimide
CAS No.	66065-85-8
Molecular Formula	C7H6Cl3NO5
Molecular Weight	306.48 g/mol
Synonyms	2,2,2-Trichloroethyl Succinimidyl Carbonate; Troc-OSu; N-(Tricloroethoxycarbonyloxy)succinimide; Succinimidyl 2,2,2-Trichloroethyl Carbonate; Troc-ONSu; NSC 334368; 2,5-Pyrrolidinedione, 1-[[(2,2,2-trichloroethoxy)carbonyl]oxy]-; Troc Succinimidyl Carbonate
EINECS	Contact for details

Quality Control

Our n-(2,2,2-Trichloroethoxycarbonyloxy)Succinimide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and production. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	118 - 122 °C
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.