Description

1-[6,7-Dimethoxy-1-(4-Methoxy-Phenyl)-3,4-Dihydro-1H-Isoquinolin-2-Yl]-Ethanone is a high-purity, complex organic compound belonging to the tetrahydroisoquinoline class, serving as a critical advanced intermediate in pharmaceutical synthesis. Its value lies in its role as a sophisticated building block for constructing complex molecular architectures, enabling the development of novel active pharmaceutical ingredients (APIs). This product is essential for research and development chemists, process chemists, and manufacturers in the pharmaceutical and fine chemical industries who require reliable, high-quality intermediates for drug discovery and production.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those targeting neurological and cardiovascular systems.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs).
• Process Chemistry: Serves as a pivotal intermediate in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs).
• Fine Chemical Synthesis: Employed in the production of specialty chemicals and complex organic molecules requiring a tetrahydroisoquinoline core structure.
• Contract Manufacturing (CMO/CDMO): A critical raw material for contract research and manufacturing organizations supporting global pharmaceutical pipelines.

Basic Information

Product Name	1-[6,7-Dimethoxy-1-(4-Methoxy-Phenyl)-3,4-Dihydro-1H-Isoquinolin-2-Yl]-Ethanone
CAS No.	66040-39-9
Molecular Formula	C20H23NO4
Molecular Weight	341.40 g/mol
Synonyms	2-Acetyl-1-(4-methoxyphenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline; 1-[1-(4-Methoxyphenyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]ethanone; 2-Acetyl-6,7-dimethoxy-1-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline; Ethanone, 1-[6,7-dimethoxy-1-(4-methoxyphenyl)-3,4-dihydro-1H-isoquinolin-2-yl]-; Tetrahydroisoquinoline derivative CAS 66040-39-9
EINECS	Contact for details

Quality Control

Our 1-[6,7-Dimethoxy-1-(4-Methoxy-Phenyl)-3,4-Dihydro-1H-Isoquinolin-2-Yl]-Ethanone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC for assay and impurity profiling, to meet the stringent requirements of pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and related substances is provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.