Description

D-Glucose-1,2,3,4,5,6,6-D7 is a stable isotope-labeled analog of D-glucose, where seven hydrogen atoms are replaced by deuterium, offering a non-radioactive tracer for advanced metabolic and biochemical research. This high-purity compound is essential for providing precise, reliable data in mass spectrometry and NMR studies, enabling detailed pathway analysis without interfering with natural biological processes. It is a critical reagent for pharmaceutical R&D, academic research, and diagnostic development in metabolism, diabetes, and cancer research.

Application

• Metabolic Flux Analysis (MFA): Used as a stable isotopic tracer to quantify intracellular metabolic pathway rates and dynamics in cell cultures and tissues.
• Mass Spectrometry (MS) Standards: Serves as an internal standard for the accurate quantification of endogenous glucose and its metabolites via LC-MS or GC-MS, improving analytical precision.
• Nuclear Magnetic Resonance (NMR) Spectroscopy: Employed in 2H-NMR studies to investigate glucose metabolism, enzyme mechanisms, and structural biology without spectral overlap from proton signals.
• Pharmaceutical Drug Development: Utilized in preclinical ADME (Absorption, Distribution, Metabolism, Excretion) studies to track the metabolic fate of new drug candidates.
• Diagnostic Assay Development: Acts a key component in calibrating and validating assays for clinical research into metabolic disorders like diabetes.
• Nutritional and Biochemical Research: Facilitates studies on carbohydrate metabolism, insulin signaling, and energy homeostasis in model organisms.

Basic Information

Product Name	D-Glucose-1,2,3,4,5,6,6-D7
CAS No.	66034-51-3
Molecular Formula	C6H5D7O6
Molecular Weight	189.18 g/mol
Synonyms	D-Glucose-d7; [1,2,3,4,5,6,6-2H7]-D-Glucose; Deuterated D-Glucose; D-(+)-Glucose-1,2,3,4,5,6,6-d7; Hexose-d7; Dextrose-d7; D-Glucose (1,2,3,4,5,6,6-D7); α-D-Glucopyranose-d7
EINECS	Contact for details

Quality Control

Every batch of D-Glucose-1,2,3,4,5,6,6-D7 is manufactured and analyzed under strict quality systems to ensure the highest isotopic and chemical purity required for sensitive research applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing isotopic enrichment, chemical purity, and analytical methods (NMR, MS, HPLC) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccation or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 98.0%
Specific Optical Rotation	+52.5° to +53.0° (c=10 in H2O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.