Description

5,5-Diphenyl-D10-Hydantoin is a deuterated analog of the anticonvulsant drug phenytoin, where ten hydrogen atoms are replaced with deuterium. This deuteration is critical for enhancing metabolic stability and reducing the rate of oxidative metabolism, making it an invaluable internal standard and reference material in analytical chemistry. It is primarily used by pharmaceutical researchers, analytical laboratories, and chemical manufacturers engaged in drug development, metabolic studies, and high-precision quantitative analysis.

Application

• Pharmaceutical Reference Standard: Serves as a certified internal standard for the accurate quantification of phenytoin and its metabolites in biological matrices using LC-MS and GC-MS.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in stable isotope labeling studies to investigate the metabolic pathways, bioavailability, and pharmacokinetic profiles of hydantoin-based drugs.
• Analytical Method Development: Essential for developing and validating robust, high-sensitivity analytical methods in compliance with FDA and ICH guidelines.
• Isotope Dilution Mass Spectrometry (IDMS): Provides high-accuracy measurements in clinical chemistry and forensic toxicology for phenytoin level monitoring.
• Chemical Synthesis Intermediate: Acts as a deuterated building block for the synthesis of more complex labeled compounds for research purposes.
• Quality Control in Manufacturing: Employed in the quality assurance and control processes of pharmaceutical production to ensure batch consistency and purity.

Basic Information

Product Name	5,5-Diphenyl-D10-Hydantoin
CAS No.	65854-97-9
Molecular Formula	C15D10N2O2
Molecular Weight	260.33 g/mol
Synonyms	Phenytoin-d10; 5,5-Diphenyl-2,4-imidazolidinedione-d10; 5,5-Diphenylhydantoin-d10; Deutrated Phenytoin; Phenytoin (phenyl-d5, hydantoin-d5); DL-5,5-Diphenylhydantoin-d10; NSC 12203-d10
EINECS	Contact for details

Quality Control

Our 5,5-Diphenyl-D10-Hydantoin is manufactured under strict quality systems to ensure high chemical purity and isotopic enrichment suitable for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity (by HPLC), isotopic purity (deuteration degree), and identity confirmation (by NMR and MS). We adhere to relevant industry standards for reference materials, and custom purity grades or specific certifications can be discussed to meet your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent absorption of moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.