Description

(4-Fluorophenyl)Methyl 1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-1H-Indol E-3-Acetate is a high-purity, non-steroidal anti-inflammatory drug (NSAID) intermediate of significant commercial and research interest. This compound is a key synthetic precursor in the development of novel pharmaceutical agents targeting inflammation and pain. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract research organizations (CROs) engaged in advanced organic synthesis. Our supply ensures consistent quality and reliable availability for critical development and production workflows.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of advanced NSAID candidates and related therapeutic molecules.
• Biochemical Research: Used as a reference standard and active probe in pharmacological studies to investigate cyclooxygenase (COX) inhibition pathways.
• Fine Chemical Synthesis: Serves as a versatile building block for the preparation of more complex indole-based derivatives with tailored biological activity.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and cGMP production of active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for methodological development in heterocyclic and medicinal chemistry.

Basic Information

Product Name	(4-Fluorophenyl)Methyl 1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-1H-Indol E-3-Acetate
CAS No.	65825-21-0
Molecular Formula	C26H21ClFNO4
Molecular Weight	465.90 g/mol
Synonyms	1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-acetic acid 4-fluorobenzyl ester; 4-Fluorobenzyl 1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-ylacetate; E-3-Acetate derivative of a substituted indole; Fluorophenylmethyl indole-3-acetate ester; Acemetacin related intermediate; Indomethacin analog intermediate; NSAID intermediate 65825-21-0
EINECS	Contact for details

Quality Control

Every batch of (4-Fluorophenyl)Methyl 1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-1H-Indol E-3-Acetate is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards and customer specifications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.