Description

Dl-Proline-D7 Hydrochloride CAS NO 65807-21-8 is a high-purity, deuterium-labeled derivative of the amino acid proline, specifically designed for advanced research and analytical applications. This stable isotope-labeled compound is essential for use as an internal standard in mass spectrometry, enabling precise quantification and reducing matrix effects in complex samples. It is a critical reagent for researchers and quality control laboratories in the pharmaceutical, metabolomics, and forensic science industries who require uncompromising isotopic purity and chemical stability for their analytical methods.

Application

• Internal Standard for LC-MS/MS and GC-MS: Primary application for accurate quantification of proline and related metabolites in biological matrices.
• Pharmaceutical Research & Drug Metabolism Studies (DMPK): Used in pharmacokinetic studies to trace drug metabolites and understand metabolic pathways.
• Clinical Diagnostics & Biomarker Discovery: Facilitates the precise measurement of proline levels in plasma, urine, or tissue samples for disease research.
• Nutritional Science and Sports Medicine: Enables research into collagen synthesis, muscle recovery, and amino acid metabolism.
• Forensic Toxicology: Serves as a reliable standard in the analysis of amino acids in forensic samples.
• Isotope Dilution Mass Spectrometry (IDMS): A key component in this gold-standard method for achieving high-accuracy results.

Basic Information

Product Name	Dl-Proline-D7 Hydrochloride
CAS No.	65807-21-8
Molecular Formula	C5H2D7NO2 • HCl
Molecular Weight	169.66 g/mol (approx.)
Synonyms	DL-Proline-d7 hydrochloride; (±)-Proline-d7 hydrochloride; (RS)-Proline-d7 hydrochloride; Pyrrolidine-2-carboxylic-2,3,3,4,4,5,5-d7 acid hydrochloride; Deuterated DL-Proline HCl; Proline (ring-D5, 2-D2) hydrochloride; Amino acid internal standard-d7
EINECS	Contact for details

Quality Control

Every batch of Dl-Proline-D7 Hydrochloride is manufactured and tested under strict quality management systems to ensure exceptional isotopic and chemical purity suitable for sensitive analytical applications. Our products undergo rigorous quality testing, including NMR and mass spectrometry, to confirm deuteration level and chemical identity, ensuring compliance with industry standards. Certificates of Analysis (COA) detailing batch-specific results for purity, isotopic enrichment, and impurities are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a cool, dry place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 98 atom % D
Chemical Purity (Titration)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.