Description

Antipyrine-D3 is a stable isotope-labeled analog of antipyrine, where three hydrogen atoms are replaced by deuterium. This compound is essential as an internal standard in quantitative analytical methods, ensuring unparalleled accuracy and reproducibility in mass spectrometry and NMR analyses. It is primarily required by pharmaceutical research laboratories, contract research organizations (CROs), and analytical service providers for drug metabolism and pharmacokinetic (DMPK) studies, bioanalytical method development, and quality control.

Application

• Internal Standard for LC-MS/MS and GC-MS quantification of antipyrine in biological matrices.
• Deuterated tracer in Drug Metabolism and Pharmacokinetic (DMPK) research.
• Reference material for NMR spectroscopy and method validation.
• Critical component in bioanalytical method development for regulatory submissions.
• Use in clinical pharmacology studies to assess cytochrome P450 enzyme activity.
• High-purity standard for pharmaceutical quality control laboratories.

Basic Information

Product Name	Antipyrine-D3
CAS No.	65566-62-3
Molecular Formula	C11H9D3N2O
Molecular Weight	191.23 g/mol
Synonyms	2,3-Dimethyl-1-phenyl-3-pyrazolin-5-one-d3; Phenazone-d3; 1,5-Dimethyl-2-phenyl-3-pyrazolone-d3; Analgesine-d3; Parodyne-d3; Sedatine-d3; Antipyrinum-d3; [2H3]-Antipyrine
EINECS	Contact for details

Quality Control

Our Antipyrine-D3 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (D-content), chemical purity by HPLC, and identity confirmation. We adhere to relevant industry standards for reference materials to guarantee reliable and reproducible performance in your critical assays.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity (by HPLC)	≥ 99.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.