Description

(1S)-1,2,3,4-Tetrahydro-6,7-Dimethoxy-1-Methyl-2-(4-Nitrophenyl)Isoquinoline is a high-purity chiral isoquinoline derivative, a critical building block in advanced pharmaceutical synthesis. This compound matters for its role as a key intermediate in developing active pharmaceutical ingredients (APIs) with specific stereochemical requirements. Pharmaceutical R&D and fine chemical manufacturers need it for the production of complex molecules, particularly in neurological and cardiovascular research applications.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, particularly for central nervous system (CNS) and cardiovascular targets.
• Asymmetric Synthesis: Utilized as a building block in catalytic and stoichiometric asymmetric reactions to introduce the tetrahydroisoquinoline scaffold.
• Medicinal Chemistry Research: Serves as a core structure for structure-activity relationship (SAR) studies and the development of new chemical entities.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.
• Process Chemistry Development: Employed in scaling up synthetic routes for potential APIs, requiring consistent quality and purity.

Basic Information

Product Name	(1S)-1,2,3,4-Tetrahydro-6,7-Dimethoxy-1-Methyl-2-(4-Nitrophenyl)Isoquinoline
CAS No.	65492-87-7
Molecular Formula	C19H22N2O4
Molecular Weight	342.39 g/mol
Synonyms	(S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-1-methyl-2-(4-nitrophenyl)isoquinoline; (1S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-1-methyl-2-(4-nitrophenyl)isoquinoline; (S)-6,7-Dimethoxy-1-methyl-2-(4-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline; (S)-1-Methyl-2-(4-nitrophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline; (S)-Tetrahydropapaverine nitro derivative; (S)-THP-NO2; (S)-1-Methyl-2-(p-nitrophenyl)-6,7-dimethoxytetrahydroisoquinoline
EINECS	Contact for details

Quality Control

Our (1S)-1,2,3,4-Tetrahydro-6,7-Dimethoxy-1-Methyl-2-(4-Nitrophenyl)Isoquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent specifications for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (S-enantiomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.