Description

Methyl 4-Chloro-3-Hydroxythiophene-2-Carboxylate is a high-purity, functionalized thiophene derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role as a versatile intermediate in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily needed by research chemists and process development scientists working on active pharmaceutical ingredients (APIs), specialty chemicals, and novel materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides, fungicides, and insecticides that require specific heterocyclic scaffolds.
• Material Science Research: Serves as a precursor for conducting polymers, organic semiconductors, and other electronic materials due to the thiophene core.
• Organic Synthesis Building Block: The reactive chloro and hydroxyl groups make it a versatile intermediate for further functionalization, including Suzuki couplings, nucleophilic substitutions, and esterifications.
• Dye and Pigment Intermediate: Employed in the development of specialized dyes and pigments where the thiophene ring contributes to color and stability properties.

Basic Information

Product Name	Methyl 4-Chloro-3-Hydroxythiophene-2-Carboxylate
CAS No.	65449-59-4
Molecular Formula	C6H5ClO3S
Molecular Weight	192.62 g/mol
Synonyms	Methyl 4-chloro-3-hydroxythiophene-2-carboxylate; 4-Chloro-3-hydroxy-2-thiophenecarboxylic acid methyl ester; 2-Thiophenecarboxylic acid, 4-chloro-3-hydroxy-, methyl ester; Methyl 4-chloro-3-hydroxy-2-thiophenecarboxylate; 3-Hydroxy-4-chlorothiophene-2-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 4-Chloro-3-Hydroxythiophene-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.