Description

1-(3,4,5-Trichlorothiophen-2-Yl)Ethan-1-One is a high-purity, halogenated thiophene derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its value lies in providing a functionalized, electron-deficient aromatic scaffold essential for constructing complex molecules with tailored properties. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS and anti-infective therapies.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the trichlorothiophene moiety contributes to biological activity and stability.
• Material Science Research: Serves as a precursor for organic electronic materials, such as conductive polymers and non-linear optical (NLO) chromophores.
• Chemical Synthesis: Acts as a versatile electrophile in cross-coupling reactions (e.g., Suzuki, Stille) and nucleophilic aromatic substitution for introducing complex side chains.
• Ligand and Catalyst Development: Utilized to create specialized ligands for metal catalysis or as a core structure in catalyst design.

Basic Information

Product Name	1-(3,4,5-Trichlorothiophen-2-Yl)Ethan-1-One
CAS No.	65434-11-9
Molecular Formula	C6H3Cl3OS
Molecular Weight	229.51 g/mol
Synonyms	2-Acetyl-3,4,5-trichlorothiophene; 3,4,5-Trichloro-2-acetylthiophene; Ethanone, 1-(3,4,5-trichloro-2-thienyl)-; 1-(3,4,5-Trichloro-2-thienyl)ethanone; 1-(3,4,5-Trichlorothiophen-2-yl)ethanone; Acetyltrichlorothiophene
EINECS	Contact for details

Quality Control

Our 1-(3,4,5-Trichlorothiophen-2-Yl)Ethan-1-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.