Description

N,n-Diethyl-N'-(6-Methyl-5H-Pyrido[3',4':4,5]Pyrrolo[2,3-G]Isoquinolin-10-Yl)Propane-1,3-Diamine is a complex, high-purity heterocyclic organic compound with a fused polycyclic structure, serving as a critical advanced intermediate in pharmaceutical research and development. Its precise molecular architecture makes it a valuable building block for synthesizing novel therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery. This compound is essential for research chemists and process development scientists in pharmaceutical and biotechnology companies who require reliable, high-quality intermediates to accelerate their discovery pipelines and scale-up processes.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, particularly for targeted cancer therapies.
• Oncology Research: Used in the synthesis of potential kinase inhibitors and other small-molecule agents designed to interfere with specific cancer cell pathways.
• CNS Drug Discovery: Serves as a building block for compounds targeting neurological disorders due to its ability to cross the blood-brain barrier.
• Chemical Biology: Employed as a molecular probe or scaffold in studying protein-ligand interactions and biological mechanisms.
• Process Chemistry & Scale-Up: Used in optimizing synthetic routes and scaling production from laboratory to pilot plant scale for clinical trial material.
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental studies in medicinal chemistry and organic synthesis.

Basic Information

Product Name	N,n-Diethyl-N'-(6-Methyl-5H-Pyrido[3',4':4,5]Pyrrolo[2,3-G]Isoquinolin-10-Yl)Propane-1,3-Diamine
CAS No.	65222-35-7
Molecular Formula	C24H28N6
Molecular Weight	400.52 g/mol
Synonyms	1,3-Propanediamine, N1,N1-diethyl-N3-(6-methyl-5H-pyrido[3',4':4,5]pyrrolo[2,3-g]isoquinolin-10-yl)-; N,N-Diethyl-N'-(6-methyl-5H-pyrido[3',4':4,5]pyrrolo[2,3-g]isoquinolin-10-yl)-1,3-propanediamine; 10-[(3-Diethylamino)propyl]amino-6-methyl-5H-pyrido[3',4':4,5]pyrrolo[2,3-g]isoquinoline; DB-289 (developmental code name); Pafuramidine (former USAN); Pafuramidine Maleate precursor
EINECS	Contact for details

Quality Control

Our N,n-Diethyl-N'-(6-Methyl-5H-Pyrido[3',4':4,5]Pyrrolo[2,3-G]Isoquinolin-10-Yl)Propane-1,3-Diamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing purity, related substances, and residual solvents are provided with every shipment. We adhere to cGMP principles for advanced intermediates to ensure consistent quality, traceability, and reliability for your critical R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and opened under controlled conditions to minimize exposure to atmospheric moisture and light. For long-term storage, consider using desiccant packs and storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to brown solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single unknown impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.