Description

L-Alanine (3-13C) is a stable isotope-labeled analog of the essential amino acid L-alanine, specifically enriched with carbon-13 at the 3-position. This high-purity labeled compound is critical for advanced research and development, providing a non-radioactive tracer for precise metabolic and biochemical studies. It is primarily utilized by research institutions, pharmaceutical developers, and diagnostic companies engaged in NMR spectroscopy, mass spectrometry, metabolic flux analysis, and the development of labeled internal standards.

Application

• Metabolic Research & Flux Analysis: Used as a 13C tracer to study amino acid metabolism, gluconeogenesis, and energy pathways in cell cultures, tissues, and whole organisms.
• NMR Spectroscopy: Serves as a crucial standard and building block for protein NMR studies, enabling structural elucidation and dynamics research.
• Mass Spectrometry (MS): Employed as an internal standard for the accurate quantification of alanine and related metabolites in LC-MS and GC-MS platforms, enhancing analytical precision.
• Pharmaceutical R&D: Integral in drug metabolism and pharmacokinetics (DMPK) studies to track the fate of drug molecules and their metabolites.
• Diagnostic Reagent Development: Used in the formulation of calibrated assays and kits for clinical diagnostics and metabolic disorder testing.
• Biochemical Synthesis: Acts as a labeled precursor in the enzymatic or chemical synthesis of more complex isotopically labeled peptides, proteins, and other biomolecules.

Basic Information

Product Name	L-Alanine (3-13C)
CAS No.	65163-25-9
Molecular Formula	C3H7NO2 (13C at position 3)
Molecular Weight	90.09 g/mol (for 13C1 isotopologue)
Synonyms	(2S)-2-Aminopropanoic-3-13C acid; L-α-Alanine-3-13C; (S)-Alanine-3-13C; Alanine-3-13C, L-; L-Alanine-3-13C; [3-13C]-L-Alanine; 3-13C-L-Alanine; Propanoic-3-13C acid, 2-amino-, (S)-
EINECS	Contact for details

Quality Control

Our L-Alanine (3-13C) is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically ≥99 atom % 13C), chemical purity (by HPLC), chiral purity, and other critical parameters. We support compliance with relevant standards for research-grade materials, and specifications can be provided to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Enrichment	≥99 atom % 13C
Assay (HPLC)	≥98.0% (on anhydrous basis)
Optical Rotation	+13.5° to +15.5° (c=10 in 1N HCl)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.