Description

n-(Benzyloxycarbonyloxy)-Phthalimide is a specialized organic reagent widely used in synthetic chemistry. This compound serves as a versatile protecting group reagent and an activated ester intermediate, enabling controlled chemical transformations. It is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly in peptide synthesis and the development of active pharmaceutical ingredients (APIs).

Application

• Peptide Synthesis: Used as a reagent for introducing the benzyloxycarbonyl (Cbz or Z) protecting group to amino acids, a critical step in solid-phase and solution-phase peptide synthesis.
• Pharmaceutical Intermediates: Acts as a key building block in the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Organic Synthesis Reagent: Functions as an efficient acylating agent and activated ester for amide bond formation under mild conditions.
• Bioconjugation Chemistry: Employed in the modification of biomolecules, such as proteins and peptides, for research and diagnostic applications.
• Polymer Chemistry: Can be utilized in the synthesis of specialized polymers and functional materials requiring protected amine groups.
• Academic & Industrial R&D: A valuable tool for chemists in research laboratories for developing new synthetic methodologies and compounds.

Basic Information

Product Name	n-(Benzyloxycarbonyloxy)-Phthalimide
CAS No.	65162-83-6
Molecular Formula	C₁₆H₁₁NO₅
Molecular Weight	297.26 g/mol
Synonyms	N-Carbobenzyloxyoxyphthalimide; N-(Benzyloxycarbonyloxy)phthalimide; Z-ONp (historical); Benzyl N-(phthalimidooxy)formate; NSC 334681; Benzyloxycarbonyloxyphthalimide; Cbz-ONP; O-(Benzyloxycarbonyl)-N-hydroxyphthalimide
EINECS	Contact for details

Quality Control

Our n-(Benzyloxycarbonyloxy)-Phthalimide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every shipment upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	105 - 110 °C
Loss on Drying	≤ 1.0 %
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.