Description

3-(3-(Trifluoromethyl)Phenyl)Prop-2-Yn-1-Ol is a specialized fluorinated aromatic alkyne derivative, serving as a versatile and high-value synthetic intermediate. Its core value lies in the trifluoromethyl group, which imparts unique electronic and lipophilic properties crucial for modifying the biological activity and stability of target molecules. This compound is essential for R&D chemists and process developers in the pharmaceutical and agrochemical industries, particularly for constructing complex molecules in drug discovery and advanced material synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the CF3 group enhances bioavailability and environmental stability.
• Material Science Research: Serves as a precursor for advanced polymers, liquid crystals, and organic electronic materials due to its rigid aromatic-alkyne structure.
• Chemical Biology Probes: Employed in the creation of tagged molecules and probes for studying enzyme mechanisms and protein interactions.
• Cross-Coupling Reactions: A valuable substrate in Sonogashira, Heck, and other palladium-catalyzed cross-coupling reactions to form complex biaryl and conjugated systems.

Basic Information

Item	Details
Product Name	3-(3-(Trifluoromethyl)Phenyl)Prop-2-Yn-1-Ol
CAS No.	65126-85-4
Molecular Formula	C10H7F3O
Molecular Weight	200.16 g/mol
Synonyms	3-[3-(Trifluoromethyl)phenyl]prop-2-yn-1-ol; 3-(3-Trifluoromethylphenyl)-2-propyn-1-ol; 3-(α,α,α-Trifluoro-m-tolyl)propargyl alcohol; m-(Trifluoromethyl)phenyl propargyl alcohol; 1-Propargyl-3-trifluoromethylbenzene; 3-(3-Trifluoromethylphenyl)propiolic alcohol; 3-(m-Trifluoromethylphenyl)prop-2-yn-1-ol
EINECS	Contact for details

Quality Control

Our production of 3-(3-(Trifluoromethyl)Phenyl)Prop-2-Yn-1-Ol adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including GC, HPLC, and NMR to verify identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment, ensuring full traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.