Description

4,4'-Diamino-2''-Chloro-2,2'-Dimethyltrityl Alcohol is a specialized trityl-protected amine derivative, a critical intermediate in advanced organic synthesis. Its value lies in its dual functionality, offering both a reactive amine group and a photolabile protecting group, enabling precise control in multi-step synthetic pathways. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for the synthesis of oligonucleotides, peptides, and complex active pharmaceutical ingredients (APIs) where selective deprotection is required.

Application

• Oligonucleotide Synthesis: Serves as a key phosphoramidite precursor for the solid-phase synthesis of DNA and RNA sequences, where the trityl group acts as a protecting group for the 5'-hydroxyl.
• Peptide Chemistry: Used in the synthesis of complex peptides and peptide nucleic acids (PNAs) to protect amino acid side chains during coupling reactions.
• Pharmaceutical Intermediates: A crucial building block for the development of novel therapeutic agents, including antivirals and gene therapy components.
• Protecting Group Chemistry: Employed in multi-step organic syntheses where selective protection and deprotection of amine functionalities are necessary.
• Bioconjugation: Facilitates the site-specific labeling and modification of biomolecules for diagnostic and research applications.
• Material Science Research: Used in the development of functionalized polymers and dendrimers with precise molecular architectures.

Basic Information

Product Name	4,4'-Diamino-2''-Chloro-2,2'-Dimethyltrityl Alcohol
CAS No.	65122-41-0
Molecular Formula	C23H23ClN2O
Molecular Weight	378.90 g/mol
Synonyms	2-Chloro-4,4'-diamino-2',2''-dimethyltrityl Alcohol; 2''-Chloro-4,4'-diamino-2,2'-dimethyltrityl Alcohol; 4,4'-Diamino-2''-chloro-2,2'-dimethyltrityl Alcohol; 1,1-Bis(4-amino-3-methylphenyl)-1-(2-chlorophenyl)methanol; 2-Chloro-α,α-bis(4-amino-3-methylphenyl)benzenemethanol; 4,4'-Diamino-2''-chloro-α,α-dimethyltrityl Alcohol; DMT-Cl-Amino Alcohol; Chloro-dimethoxytrityl protected diamine.
EINECS	Contact for details

Quality Control

Our 4,4'-Diamino-2''-Chloro-2,2'-Dimethyltrityl Alcohol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, critical for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality commitment aligns with the standards required for GMP-grade intermediates and research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is light-sensitive (store away from light) and may be moisture-sensitive; therefore, containers should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.