Description

Imipramine-D3 is a stable isotope-labeled analog of the tricyclic antidepressant imipramine, where three hydrogen atoms are replaced by deuterium. This high-purity reference standard is essential for ensuring accuracy and reliability in quantitative analytical methods. It is primarily used by pharmaceutical research laboratories, contract research organizations (CROs), and analytical testing facilities for applications such as method development, validation, and pharmacokinetic studies.

Application

• Internal Standard for LC-MS/MS: Serves as a critical internal standard in Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) for the precise quantification of imipramine and its metabolites in biological matrices.
• Pharmacokinetic and Bioavailability Studies: Enables accurate tracking and measurement of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and preclinical research.
• Forensic and Clinical Toxicology: Used in analytical assays to confirm and quantify imipramine levels in forensic investigations and therapeutic drug monitoring (TDM) programs.
• Drug Metabolism Research: Facilitates the study of metabolic pathways and the identification of metabolites due to its isotopic distinction from the parent compound.
• Pharmaceutical Quality Control: Employed in the development and validation of analytical methods for the quality assurance of active pharmaceutical ingredients (APIs) and finished drug products.
• Regulatory Compliance and Method Validation: Supports compliance with regulatory guidelines (e.g., FDA, EMA) that often require the use of stable isotope-labeled internal standards for bioanalytical method validation.

Basic Information

Item	Detail
Product Name	Imipramine-D3
CAS No.	65100-49-4
Molecular Formula	C19H21D3N2
Molecular Weight	284.41 g/mol
Synonyms	5-(3-Dimethylaminopropyl)-10,11-dihydro-5H-dibenz[b,f]azepine-d3; Imipramine (methyl-d3); Imipramine-d3 (deuterated); 3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine-d3; N-(γ-Dimethylaminopropyl)iminodibenzyl-d3; Tofranil-d3; Imipramine Deuterated Standard
EINECS	Contact for details

Quality Control

Every batch of Imipramine-D3 is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high standards required for research and regulatory applications. A Certificate of Analysis (COA) is supplied with each shipment, detailing parameters such as isotopic purity, chemical purity, and absence of impurities. Our quality commitment supports compliance with relevant pharmacopeial and regulatory expectations for reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Content)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.