Description

3-(10,11-Dihydro-5H-Dibenzo[B,F]Azepin-5-Yl)-n-Methyl-n-( 2 H 3 )Methyl-1-Propanamine CAS NO 65100-48-3 is a deuterated derivative of a tricyclic dibenzazepine compound, serving as a crucial stable isotope-labeled building block for advanced research and development. This compound is of significant value for its use in creating internal standards and labeled analogs for pharmacokinetic and metabolic studies. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in drug discovery and analytical method development.

Application

• Deuterated Internal Standard for LC-MS/MS: Used as a high-purity reference standard in quantitative bioanalytical methods to ensure accuracy and precision in drug concentration measurements.
• Metabolic Pathway Tracing: Employed in drug metabolism and pharmacokinetics (DMPK) studies to track and identify metabolites using mass spectrometry.
• Pharmaceutical Impurity Profiling: Serves as a marker or reference compound in the identification and quantification of process-related impurities or degradation products.
• Isotope Dilution Analysis: Critical for advanced analytical techniques requiring stable isotope dilution to achieve superior quantitative results in complex matrices.
• Precursor for Labeled Active Pharmaceutical Ingredients (APIs): Acts as a key synthetic intermediate in the preparation of deuterium-labeled drug candidates for clinical trials.
• Neuropharmacology Research: Used in the study of tricyclic compound mechanisms and receptor interactions, leveraging the isotopic label for precise tracking.

Basic Information

Product Name	3-(10,11-Dihydro-5H-Dibenzo[B,F]Azepin-5-Yl)-n-Methyl-n-( 2 H 3 )Methyl-1-Propanamine
CAS No.	65100-48-3
Molecular Formula	C19H22D3N2 (Note: D denotes Deuterium)
Molecular Weight	~284.44 g/mol (Calculated for monoisotopic mass)
Synonyms	N-Methyl-3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-(trideuteriomethyl)propan-1-amine
N-Methyl-N-(trideuteriomethyl)-3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propan-1-amine
Deuterated Desipramine Derivative
N-Methyl-N-(CD3)-3-(5H-Dibenzo[b,f]azepin-5-yl)propylamine
3-(5H-Dibenzo[b,f]azepin-5-yl)-N-methyl-N-(methyl-d3)-1-propanamine
Desipramine-d3 (specific to the N-CD3 labeled form)
Dibenzoazepine-d3 Derivative
EINECS	Contact for details

Quality Control

Our stable isotope-labeled compounds are produced and handled under strict quality protocols to ensure isotopic purity and chemical integrity, critical for sensitive analytical applications. Each batch is supported by comprehensive analytical data including NMR (¹H, ¹³C) for structural confirmation, high-resolution mass spectrometry (HRMS) for exact mass verification, and HPLC for chemical purity assessment. Certificates of Analysis (COA) detailing isotopic enrichment (D%), chemical purity, and batch-specific data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C to maximize stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.