Description

Imipramine-D6 is a stable isotope-labeled analog of the tricyclic antidepressant imipramine, where six hydrogen atoms are replaced by deuterium. This compound is an essential internal standard for the precise and accurate quantification of imipramine in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and forensic toxicology units engaged in drug metabolism, pharmacokinetic studies, and bioanalytical method development and validation.

Application

• Use as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the quantitative analysis of imipramine.
• Critical for bioanalytical method development and validation in pharmaceutical research and clinical trials.
• Facilitates drug metabolism and pharmacokinetic (DMPK) studies by enabling precise tracking of the parent drug.
• Applied in forensic and clinical toxicology for the accurate determination of imipramine levels in biological samples.
• Supports quality control and stability testing of imipramine-based pharmaceutical formulations.
• Essential in academic research investigating the pharmacological profile and metabolic pathways of tricyclic antidepressants.

Basic Information

Product Name	Imipramine-D6
CAS No.	65100-45-0
Molecular Formula	C19H18D6N2
Molecular Weight	286.44 g/mol
Synonyms	5-(3-Dimethylaminopropyl)-10,11-dihydro-5H-dibenzo[b,f]azepine-d6; Desipramine Impurity D6; 10,11-Dihydro-N,N-dimethyl-5H-dibenzo[b,f]azepine-5-propanamine-d6; Imipramine (hexadeuterated); Imipramine-d6 Internal Standard; Deuterated Imipramine; N-(γ-Methylaminopropyl)iminodibenzyl-d6
EINECS	Contact for details

Quality Control

Every batch of Imipramine-D6 is manufactured and analyzed under strict quality management protocols to ensure exceptional isotopic purity and chemical integrity, suitable for sensitive analytical applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing isotopic enrichment, chemical purity, and analytical results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.