Description

Morphine-3,6-Diglucuronide Tetrahydrate, Dea Schedule Ii CAS NO 64947-41-7 is a major, pharmacologically active metabolite of morphine, formed via glucuronidation in the liver. This compound is of critical importance for pharmaceutical research, forensic toxicology, and clinical diagnostics, serving as a primary reference standard. It is essential for laboratories requiring precise quantification and qualification of morphine metabolites in biological matrices. Target users include analytical chemists, forensic scientists, and researchers in pharmaceutical development and clinical pharmacology.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the calibration and validation of analytical methods in drug metabolism and pharmacokinetic (DMPK) studies.
• Forensic Toxicology: Critical for the accurate identification and quantification of morphine and its metabolites in biological samples (e.g., urine, blood) for legal and workplace testing.
• Clinical Research & Diagnostics: Used in developing and verifying diagnostic assays to monitor patient opioid metabolism, aiding in pain management and addiction treatment studies.
• Biomarker Research: Serves as a key biomarker in studies investigating individual metabolic variations, drug-drug interactions, and pharmacogenomics related to opioid therapy.
• Method Development & Validation: Essential for developing high-performance liquid chromatography (HPLC), liquid chromatography-mass spectrometry (LC-MS/MS), and immunoassay techniques in analytical laboratories.
• Regulatory Compliance & Quality Control: Supports quality assurance processes in pharmaceutical manufacturing and testing laboratories to comply with FDA, EMA, and other regulatory guidelines.

Basic Information

Product Name	Morphine-3,6-Diglucuronide Tetrahydrate, Dea Schedule Ii CAS NO 64947-41-7
CAS No.	64947-41-7
Molecular Formula	C34H44N2O20 • 4H2O
Molecular Weight	848.80 g/mol (Tetrahydrate)
Synonyms	Morphine-3,6-diglucuronide; Morphine 3,6-Di-O-β-D-Glucuronide Tetrahydrate; Morphine Diglucuronide; M3G6G; M-3,6-G; 3,6-Di-O-β-D-glucopyranuronosyl morphine; Norcotsin-3,6-diglucuronide; Morphine bisglucuronide
EINECS	Contact for details

Quality Control

Every batch of Morphine-3,6-Diglucuronide Tetrahydrate is produced and tested under strict quality management systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with the high-purity standards required for reference materials. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	7.0% - 9.0% (Theoretical for Tetrahydrate: ~8.5%)
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.