Description

Ethyl 2-Bromo-2-Methyl-D3-Propionate-3,3,3-D3 is a high-purity, deuterium-labeled isotopologue of ethyl 2-bromo-2-methylpropionate, serving as a critical building block for advanced research and synthesis. This compound is essential for creating isotopically labeled molecules, which are indispensable in mechanistic studies, metabolic pathway tracing, and quantitative mass spectrometry. It is primarily utilized by pharmaceutical R&D laboratories, agrochemical researchers, and analytical chemistry specialists who require precise molecular tools for drug discovery and environmental fate studies.

Application

• Pharmaceutical Research: As a deuterated synthon for the preparation of isotopically labeled active pharmaceutical ingredients (APIs) and metabolites for pharmacokinetic and bioanalytical studies.
• Mechanistic Investigation: Used as a tracer in reaction mechanism elucidation, leveraging the kinetic isotope effect (KIE) to study reaction pathways.
• Mass Spectrometry Standards: Serves as an internal standard or reference compound in LC-MS and GC-MS analyses to ensure accurate quantification and minimize matrix effects.
• Agrochemical Development: Employed in the synthesis of labeled pesticides and herbicides to study their environmental degradation, metabolism, and residue analysis.
• Organic Synthesis: A versatile alkylating agent and precursor for introducing the tert-butyl-d9 moiety into complex organic molecules.
• Metabolomics & Proteomics: Facilitates the development of stable isotope labeling by amino acids in cell culture (SILAC) and other quantitative proteomics techniques.

Basic Information

Product Name	Ethyl 2-Bromo-2-Methyl-D3-Propionate-3,3,3-D3
CAS No.	64768-38-3
Molecular Formula	C6H8D3BrO2
Molecular Weight	200.09 g/mol (for C6H8D379BrO2)
Synonyms	Ethyl 2-Bromo-2-(methyl-d3)propionate-3,3,3-d3; Ethyl α-Bromoisobutyrate-d6; Ethyl 2-Bromo-2-methylpropionate-d6; Ethyl 2-Bromo-2-(trideuteriomethyl)propionate-3,3,3-d3; Deuterated Ethyl 2-Bromoisobutyrate; Ethyl 2-Bromo-2-methyl-d3-propionate-3,3,3-d3; (2-Bromo-2-methyl-d3-propionic acid-3,3,3-d3) ethyl ester
EINECS	Contact for details

Quality Control

Our deuterated chemicals are produced and tested under stringent quality protocols to ensure isotopic purity, chemical purity, and batch-to-batch consistency, which are critical for research integrity. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results from NMR (for deuterium incorporation), GC/HPLC (for chemical purity), and other relevant analyses. We adhere to cGMP principles for laboratory chemicals, and our quality system supports compliance with global regulatory frameworks for research materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is sensitive to light and strong acids/organic solvents; ensure the storage area is free from such incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Isotopic Purity (NMR)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.