Description

5-Bromo-4-nitrothiophene-2-sulfonamide is a high-purity, multi-functional heterocyclic sulfonamide building block of significant interest in advanced organic synthesis. Its unique molecular architecture, featuring bromo and nitro substituents on a thiophene-sulfonamide core, makes it a versatile precursor for constructing complex molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in areas targeting enzymes where the sulfonamide group acts as a pharmacophore.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging its reactive halogen and nitro groups for further functionalization.
• Material Science Precursor: Serves as a building block for functionalized polymers and organic electronic materials due to the electron-deficient thiophene system.
• Chemical Biology Probe: Utilized in the design of activity-based probes and inhibitors for studying biological pathways involving sulfonamide-sensitive targets.
• Dye and Pigment Synthesis: Acts as an intermediate in the production of specialized dyes and pigments where the nitro and bromo groups influence color and stability.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create diverse biaryl and alkynyl structures.

Basic Information

Product Name	5-Bromo-4-nitrothiophene-2-sulfonamide
CAS No.	64729-06-2
Molecular Formula	C4H3BrN2O4S2
Molecular Weight	286.11 g/mol
Synonyms	5-Bromo-4-nitrothiophene-2-sulfonamide; 2-Thiophenesulfonamide, 5-bromo-4-nitro-; 5-Bromo-4-nitro-2-thiophenesulfonamide; 4-Nitro-5-bromothiophene-2-sulfonamide; 5-Bromo-4-nitrothiophene-2-sulphonamide; 64729-06-2; AKOS005258525; BRN 1217266; CS-W009767; FT-0658847; NS00023826; SCHEMBL1552041; 5-Br-4-NO2-Thiophene-2-SO2NH2
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-4-nitrothiophene-2-sulfonamide is manufactured and tested under a strict quality management system. We employ advanced analytical techniques including HPLC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your R&D and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.