Description

1,2-Dimethyl-D3-Imidazole (1-Methyl-D3) is a deuterium-labeled isotopologue of 1,2-dimethylimidazole, a key heterocyclic building block. This compound is specifically valued for its role as a stable isotope-labeled internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy in analytical measurements. It is primarily required by researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for applications in drug metabolism studies (DMPK), proteomics, and the synthesis of labeled compounds.

Application

• Internal Standard for LC-MS/MS: Critical for accurate quantification in bioanalytical methods for pharmacokinetic and metabolomic studies.
• Pharmaceutical Research: Used in the synthesis of deuterium-labeled drug candidates and metabolites for Drug Metabolism and Pharmacokinetics (DMPK) research.
• Proteomics & Metabolomics: Serves as a stable isotope tag or reference standard in high-throughput screening and biomarker discovery.
• Agrochemical Development: Employed in the analysis of pesticide residues and environmental fate studies using isotope dilution techniques.
• Chemical Synthesis: Acts as a deuterated precursor or ligand in the development of novel materials and catalysts.
• NMR Spectroscopy: Useful as a solvent or shift reagent in nuclear magnetic resonance studies due to its deuterium content.

Basic Information

Product Name	1,2-Dimethyl-D3-Imidazole (1-Methyl-D3)
CAS No.	64678-68-8
Molecular Formula	C5H6D3N2
Molecular Weight	100.15 g/mol
Synonyms	1,2-Dimethyl-1H-imidazole-d3; 1-Methyl-d3-2-methylimidazole; 1,2-Dimethylimidazole-d3; (1-Methyl-d3)imidazole; 1-(Methyl-d3)-2-methyl-1H-imidazole; Deuterated 1,2-Dimethylimidazole; 1,2-Dimethylimidazole (methyl-d3); Imidazole, 1,2-dimethyl-, 1-(methyl-d3)-
EINECS	Contact for details

Quality Control

Our 1,2-Dimethyl-D3-Imidazole is produced under strict quality protocols to ensure high isotopic purity and chemical integrity, essential for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (D-atom %), chemical purity, and identity confirmation. We adhere to cGMP principles where applicable to support regulatory filings in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-atom %)	≥ 98.0% (by MS)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.