Description

(5Alpha)-17-(Cyclobutylcarbonyl)-4,5-Epoxy-14-Hydroxy-3-Methoxymorphinan-6-One is a high-purity, semi-synthetic opioid derivative with a complex morphinan structure, valued for its role as a critical pharmaceutical intermediate. Its precise stereochemistry and functional groups make it an essential building block for advanced medicinal chemistry research and development. This compound is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing and producing specialized analgesic and therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potent opioid analgesics and related therapeutic compounds.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to develop new central nervous system (CNS) active molecules.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Biochemical Research: Employed in studies investigating opioid receptor binding, signaling pathways, and pharmacological profiles.
• Process Development: Utilized in the scale-up and optimization of synthetic routes for complex active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(5Alpha)-17-(Cyclobutylcarbonyl)-4,5-Epoxy-14-Hydroxy-3-Methoxymorphinan-6-One
CAS No.	64643-72-7
Molecular Formula	C24H29NO6
Molecular Weight	427.49 g/mol
Synonyms	17-Cyclobutylcarbonyl-4,5α-epoxy-14-hydroxy-3-methoxymorphinan-6-one; 4,5α-Epoxy-14-hydroxy-3-methoxy-17-cyclobutylcarbonylmorphinan-6-one; 6-Oxomorphinan derivative; Buprenorphine related intermediate; Cyclobutylcarbonylnaltrexone derivative; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our (5Alpha)-17-(Cyclobutylcarbonyl)-4,5-Epoxy-14-Hydroxy-3-Methoxymorphinan-6-One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory and quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.