Description

(5Alpha)-17-(Cyclobutylmethyl)-4,5-Epoxy-14-Hydroxy-3-Methoxymorphinan-6-One is a high-purity synthetic morphinan derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate or reference standard for the synthesis and analytical characterization of novel therapeutic agents targeting the central nervous system. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of fine chemicals and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthetic pathway for novel opioid receptor modulators and other CNS-active compounds.
• Reference Standard: Used in analytical chemistry for method development, validation, and quality control (QC/QA) of related APIs and finished drug products.
• Biochemical Research: Employed in pharmacological studies to investigate receptor binding affinity, selectivity, and structure-activity relationships (SAR).
• Process Development: Serves as a model compound for optimizing chemical synthesis routes, including catalysis and purification techniques.
• Regulatory Compliance: Essential for generating impurity profiles and conducting stability studies required for regulatory filings (e.g., FDA, EMA).

Basic Information

Item	Details
Product Name	(5Alpha)-17-(Cyclobutylmethyl)-4,5-Epoxy-14-Hydroxy-3-Methoxymorphinan-6-One
CAS No.	64643-71-6
Molecular Formula	C23H29NO5
Molecular Weight	399.48 g/mol
Synonyms	17-Cyclobutylmethyl-4,5α-epoxy-14-hydroxy-3-methoxy-6-oxomorphinan; 6-Oxo-17-(cyclobutylmethyl)-4,5α-epoxy-3-methoxy-14-hydroxymorphinan; Noroxymorphone Cyclobutylmethyl Derivative; 14-Hydroxy-3-methoxy-17-cyclobutylmethyl-4,5α-epoxymorphinan-6-one
EINECS	Contact for details

Quality Control

Our (5Alpha)-17-(Cyclobutylmethyl)-4,5-Epoxy-14-Hydroxy-3-Methoxymorphinan-6-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (IR, NMR, MS). We provide comprehensive Certificates of Analysis (COA) detailing all specifications, ensuring traceability and compliance with cGMP guidelines for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.