Description

Benzimidazole-4,5,6,7-D4 is a deuterated analog of the fundamental benzimidazole heterocycle, where four hydrogen atoms are replaced with deuterium. This isotopic labeling is critical for applications requiring enhanced analytical precision and metabolic stability studies. It serves as a key intermediate and internal standard for researchers and manufacturers in the pharmaceutical and agrochemical sectors. The compound is essential for developing and analyzing deuterated active pharmaceutical ingredients (APIs) and other specialty chemicals.

Application

• Internal Standard for Quantitative Analysis: Used as a stable isotope-labeled internal standard in LC-MS and GC-MS for the accurate quantification of benzimidazole derivatives and their metabolites.
• Pharmaceutical Research: A vital building block for synthesizing deuterated drug candidates, leveraging the kinetic isotope effect to potentially improve metabolic stability, bioavailability, and pharmacokinetic profiles.
• Agrochemical Development: Employed in the research and synthesis of novel, labeled agrochemicals and plant growth regulators for tracing and efficacy studies.
• Metabolic Pathway Tracing: Facilitates the study of drug metabolism and biochemical pathways in pharmacokinetic and toxicological research.
• NMR Spectroscopy: Serves as a valuable probe in nuclear magnetic resonance (NMR) spectroscopy due to the distinct properties of deuterium nuclei.
• Material Science Research: Used in the development of advanced organic materials, including ligands for catalysis and components for organic electronics.

Basic Information

Product Name	Benzimidazole-4,5,6,7-D4
CAS No.	64531-29-9
Molecular Formula	C7H2D4N2
Molecular Weight	122.16 g/mol
Synonyms	1H-Benzo[d]imidazole-4,5,6,7-d4; Benzimidazole-d4 (4,5,6,7-D4); 1,3-Diazaindene-d4; BZI-d4; 1H-Benzimidazole-4,5,6,7-d4; Deuterated Benzimidazole (D4); Benzimidazole (4,5,6,7-tetradeutero); Azindole-d4
EINECS	Contact for details

Quality Control

Every batch of Benzimidazole-4,5,6,7-D4 is produced and tested under strict quality management protocols to ensure high isotopic purity and chemical integrity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed data on isotopic enrichment, chemical purity, and identity confirmation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-content)	≥98 atom % D
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.