Description

D-Codeine is a specific stereoisomer of codeine, an important alkaloid derived from the opium poppy, with the CAS registry number 64520-25-8. This compound is valued for its role as a key chiral intermediate and reference standard in advanced pharmaceutical research and development. It is primarily utilized by manufacturers and research institutions in the pharmaceutical, analytical chemistry, and fine chemical synthesis sectors who require high-purity, well-characterized compounds for process development and quality control.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral building block in the synthesis of specialized opioid analgesics and antitussive medications.
• Analytical Reference Standard: Used for method development, calibration, and quality control in HPLC, GC, and LC-MS analyses within pharmaceutical QC/QA laboratories.
• Biochemical Research: Employed in studies investigating opioid receptor binding, metabolic pathways, and stereoselective enzymatic processes.
• Process Chemistry: Acts as a starting material or intermediate for the preparation of deuterated or other isotopically labeled codeine analogs for research purposes.
• Impurity Standard: Used to identify, quantify, and control the D-isomer as a potential stereochemical impurity in batches of medicinal codeine (the L-isomer).

Basic Information

Product Name	D-Codeine
CAS No.	64520-25-8
Molecular Formula	C18H21NO3
Molecular Weight	299.37 g/mol
Synonyms	(+)-Codeine; D-(+)-Codeine; Dextro-Codeine; (5R,6R,9R,13S,14R)-4,5-Epoxy-3-methoxy-17-methylmorphinan-6-ol; 64520-25-8; Codeine D-isomer; (+)-Methylmorphine; Dextrorotatory Codeine
EINECS	Contact for details

Quality Control

Our D-Codeine is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) providing full specifications and test results is available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider inert atmosphere protection.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (anhydrous basis)
Chiral Purity (HPLC)	≥99.0% D-isomer
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.