Description

1H-Indole-2-Carbonyl Chloride, 5-Chloro- (9Ci) is a high-purity, reactive chemical intermediate essential for advanced organic synthesis. Its value lies in its role as a key acylating agent for constructing complex indole-based molecular frameworks, which are prevalent in active pharmaceutical ingredients and agrochemicals. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for developing novel compounds and scaling up production processes.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, leveraging the indole core for biological activity.
• Material Science Research: Serves as a precursor for functionalized polymers and organic electronic materials due to its reactive acid chloride group and aromatic structure.
• Chemical Biology & Proteomics: Employed as a derivatization agent or linker for modifying biomolecules and studying protein interactions.
• Academic & Contract Research: A valuable reagent for methodological development in organic chemistry and for creating specialized compound libraries.

Basic Information

Item	Detail
Product Name	1H-Indole-2-Carbonyl Chloride, 5-Chloro- (9Ci)
CAS No.	64507-05-7
Molecular Formula	C9H5Cl2NO
Molecular Weight	214.05 g/mol
Synonyms	5-Chloro-1H-indole-2-carbonyl chloride; 5-Chloroindole-2-carbonyl chloride; 5-Chloro-1H-indole-2-carboxylic acid chloride; 2-(Chlorocarbonyl)-5-chloro-1H-indole; 5-Chloro-2-indolecarbonyl chloride; 5-Chloroindole-2-carboxylic acid chloride; 64507-05-7 (CAS)
EINECS	Contact for details

Quality Control

Our 1H-Indole-2-Carbonyl Chloride, 5-Chloro- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, NMR and IR for structural confirmation, and Karl Fischer titration for moisture content. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.