Description

4,4'-Diamino-2''-Chloro-3,3'-Dimethyltrityl Alcohol is a specialized trityl-protected intermediate of significant importance in advanced organic synthesis. This compound matters for its role as a key building block in the synthesis of complex molecules, particularly in the pharmaceutical and biotechnology sectors. It is primarily needed by research institutions and manufacturers engaged in the development of oligonucleotides, peptides, and other fine chemicals where precise amino group protection and deprotection strategies are critical.

Application

• Oligonucleotide Synthesis: Serves as a crucial protecting group reagent for exocyclic amino functions in nucleoside phosphoramidite chemistry, enabling the automated synthesis of DNA and RNA sequences.
• Peptide Chemistry: Used for the selective protection of amino acids during solid-phase peptide synthesis (SPPS), facilitating the construction of complex polypeptides.
• Pharmaceutical Intermediate: Acts as a key synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs) and investigational new drugs.
• Bioconjugation & Labeling: Employed in the preparation of labeled probes and diagnostic agents where a stable, cleavable linker is required.
• Material Science Research: Investigated for use in creating novel polymeric materials and dendrimers with specific functional properties.
• Academic & Industrial R&D: Utilized in methodological development and scale-up processes for novel synthetic routes in fine chemical production.

Basic Information

Product Name	4,4'-Diamino-2''-Chloro-3,3'-Dimethyltrityl Alcohol
CAS No.	64346-28-7
Molecular Formula	C23H23ClN2O
Molecular Weight	378.90 g/mol
Synonyms	2-Chloro-4,4'-diamino-3,3'-dimethyltrityl Alcohol; 4,4'-Diamino-2''-chloro-3,3'-dimethyltrityl Alcohol; 2-Chloro-4,4'-bis(amino)-3,3'-dimethyltrityl Alcohol; 4,4'-Diamino-2-chloro-3,3'-dimethyltriphenylmethanol; DMT-Cl(NH2)2-OH; Chloro-Dimethyl-Diamino-Trityl Alcohol; CAS 64346-28-7
EINECS	Contact for details

Quality Control

Our 4,4'-Diamino-2''-Chloro-3,3'-Dimethyltrityl Alcohol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive synthetic applications. Certificates of Analysis (COA) detailing batch-specific results are available upon request, supporting your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake, which can affect stability and performance. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.