Description

Acetaminophen-D4 CAS NO 64315-36-2 is a stable isotope-labeled analog of the common analgesic and antipyretic drug, acetaminophen, where four hydrogen atoms are replaced by deuterium. This high-purity compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical measurements. It is a critical tool for pharmaceutical research, clinical laboratories, and forensic toxicology professionals requiring precise drug metabolism and pharmacokinetic (DMPK) studies.

Application

• Internal Standard for LC-MS/MS: Primary application in liquid chromatography-tandem mass spectrometry for the accurate quantification of acetaminophen in biological matrices like plasma, serum, and urine.
• Drug Metabolism Studies: Used in pharmacokinetic (PK) and pharmacodynamic (PD) research to trace and quantify metabolites, enabling detailed studies of drug absorption, distribution, metabolism, and excretion (ADME).
• Forensic and Clinical Toxicology: Critical for confirming and precisely measuring acetaminophen levels in overdose cases and therapeutic drug monitoring (TDM) protocols.
• Pharmaceutical Quality Control: Serves as a reference standard in the development and validation of analytical methods for drug formulation analysis and impurity profiling.
• Biomedical Research: Facilitates proteomic and metabolomic studies investigating the biochemical pathways and potential toxicities associated with acetaminophen.

Basic Information

Product Name	Acetaminophen-D4
CAS No.	64315-36-2
Molecular Formula	C8H5D4NO2
Molecular Weight	155.18 g/mol
Synonyms	Paracetamol-D4; 4'-Hydroxyacetanilide-D4; APAP-D4; N-(4-Hydroxyphenyl)acetamide-D4; Deuterated Acetaminophen; [2H4]-Acetaminophen; 4-Acetamidophenol-D4; N-Acetyl-p-aminophenol-D4
EINECS	Contact for details

Quality Control

Every batch of Acetaminophen-D4 is manufactured and tested to meet the stringent requirements for an isotopic internal standard. Our quality assurance includes comprehensive analysis to ensure high chemical and isotopic purity, supported by detailed Certificates of Analysis (COA). The product is suitable for use under current Good Manufacturing Practice (cGMP) conditions for research and analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0% (Chemical Purity)
Isotopic Purity (D-content)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.