Description

2(1H)-Isoquinolinepropanoic Acid,1-[(3,4-Dimethoxyphenyl)Methyl]-3,4-Dihydro-6,7-Dimethoxy-, 1,5-Pentanediyl Ester, (R*,R*)-(-)-, Ethanedioate is a high-purity, stereochemically defined chemical intermediate of significant interest in advanced organic synthesis. This compound matters for its role as a sophisticated building block in the development of complex, biologically active molecules, offering precise structural control. It is primarily needed by research institutions and pharmaceutical companies engaged in the synthesis of novel therapeutic agents, particularly within medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key chiral building block for the research and development of new active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and cardiovascular drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its complex, multi-functional isoquinoline core structure.
• Process Chemistry: Serves as a critical intermediate in the scale-up and optimization of synthetic routes for target molecules in pilot plant and commercial manufacturing.
• Asymmetric Synthesis: Utilized in chiral pool synthesis and the construction of enantiomerically enriched compounds for preclinical and clinical studies.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Chemical Biology Probes: Potential use in the design and synthesis of molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	2(1H)-Isoquinolinepropanoic Acid,1-[(3,4-Dimethoxyphenyl)Methyl]-3,4-Dihydro-6,7-Dimethoxy-, 1,5-Pentanediyl Ester, (R*,R*)-(-)-, Ethanedioate
CAS No.	64228-84-8
Molecular Formula	C31H39NO10 • C2H2O4
Molecular Weight	Contact for details
Synonyms	(R*,R*)-(-)-1,5-Pentanediyl 1-[(3,4-Dimethoxyphenyl)methyl]-3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinepropanoate Ethanedioate; 1,5-Pentanediyl 1-[(3,4-dimethoxyphenyl)methyl]-3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinepropanoate (R*,R*)-(-)- oxalate; (-)-1,5-Pentanediol ester of 1-[(3,4-dimethoxyphenyl)methyl]-3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinepropanoic acid oxalate; Tetrandrine derivative intermediate; Bisbenzylisoquinoline alkaloid analog; Oxalate salt of the 1,5-pentanediyl ester.
EINECS	Contact for details

Quality Control

Our 2(1H)-Isoquinolinepropanoic Acid,1-[(3,4-Dimethoxyphenyl)Methyl]-3,4-Dihydro-6,7-Dimethoxy-, 1,5-Pentanediyl Ester, (R*,R*)-(-)-, Ethanedioate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity and impurity profiling, to ensure it meets the exacting standards required for pharmaceutical R&D. A Certificate of Analysis (COA) detailing identity, purity, and specific tests is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥97.0%
Chiral Purity	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.