Description

Oltipraz CAS NO 64224-21-1 is a synthetic dithiolethione compound with significant research and pharmaceutical interest. It is primarily recognized for its potent chemopreventive and antioxidant properties, functioning as an inducer of phase II detoxifying enzymes. This compound is of critical value to researchers and developers in the pharmaceutical and life sciences sectors. Its applications are focused on advanced studies in oncology, hepatoprotection, and the modulation of cellular defense mechanisms.

Application

• Pharmaceutical Research & Development: A key investigational agent in chemoprevention studies, particularly for liver, colon, and bladder cancers.
• Biochemical Research: Used as a potent activator of the Nrf2 signaling pathway to study cellular antioxidant response and oxidative stress.
• Hepatoprotective Studies: Investigated for its potential to protect against chemical-induced liver injury and fibrosis.
• Antiparasitic Research: Studied for activity against Schistosoma species and other parasites.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Preclinical Development: Utilized in animal models to evaluate efficacy, pharmacokinetics, and toxicity profiles for potential therapeutic candidates.

Basic Information

Product Name	Oltipraz
CAS No.	64224-21-1
Molecular Formula	C8H6N2OS2
Molecular Weight	226.28 g/mol
Synonyms	4-Methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione; RP 35972; 1,2-Dithiolo[4,3-b]pyrazine-5(4H)-thione, 6-methyl-; 5-(2-Pyrazinyl)-4-methyl-1,2-dithiole-3-thione; 6-Methyl-1,2-dithiolo[4,3-b]pyrazine-5(4H)-thione
EINECS	Contact for details

Quality Control

Our Oltipraz is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assay by HPLC, and control of related substances. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.