Description

5-[2-(Dimethylamino)Propyl]-5H-Dibenz[B,F]Azepine is a high-purity, advanced pharmaceutical intermediate with a complex tricyclic structure. This compound is valued for its role as a critical building block in the synthesis of active pharmaceutical ingredients (APIs), particularly in the central nervous system (CNS) therapeutic area. It is essential for research institutions and pharmaceutical manufacturers engaged in the development and production of novel neuroactive drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of tricyclic antidepressant and antipsychotic drug candidates.
• Neurological Research: Used in academic and industrial R&D for studying receptor binding and developing new CNS-targeting molecules.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a core structural unit in multi-step synthetic routes for final drug substances.
• Chemical Reference Standard: Employed as a high-purity standard for analytical method development and quality control in pharmaceutical laboratories.
• Process Chemistry: Utilized in scale-up and optimization studies for the commercial manufacturing of specialized pharmaceuticals.

Basic Information

Product Name	5-[2-(Dimethylamino)Propyl]-5H-Dibenz[B,F]Azepine
CAS No.	63918-76-3
Molecular Formula	C19H22N2
Molecular Weight	278.40 g/mol
Synonyms	5-[2-(Dimethylamino)propyl]dibenz[b,f]azepine; 5-(2-Dimethylaminopropyl)-5H-dibenz[b,f]azepine; 5H-Dibenz[b,f]azepine, 5-[2-(dimethylamino)propyl]-; Desmethyldesipramine Impurity; Desipramine Related Compound A; Norclomipramine; Norclomipramine (Impurity of Clomipramine); 10,11-Dihydro-5-(3-dimethylaminopropyl)-5H-dibenz[b,f]azepine
EINECS	Contact for details

Quality Control

Our 5-[2-(Dimethylamino)Propyl]-5H-Dibenz[B,F]Azepine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical intermediates. A detailed Certificate of Analysis (COA) documenting purity, related substances, and residual solvents is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.