Description

1,2,3,4,5,6-Hexahydro-3-Cyclobutylmethyl-6-Ethyl-1-Methyl-2,6-Methano-3-Benzazocin-8-Ol is a complex, high-purity synthetic organic compound belonging to the benzazocine class, valued for its specific stereochemistry and functional groups. This compound matters as a critical advanced pharmaceutical intermediate or research chemical for developing novel therapeutic agents, particularly in central nervous system (CNS) research. It is needed by R&D laboratories, pharmaceutical development units, and fine chemical manufacturers focused on innovative drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of potential analgesic or neuropharmacological active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies targeting opioid or other CNS receptors.
• Process Development & Scale-Up: Employed in optimizing synthetic routes for the production of complex heterocyclic compounds under cGMP conditions.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Academic & Institutional Research: Utilized in universities and research institutes for studying novel organic reactions and heterocyclic chemistry.
• Preclinical Studies: May be formulated for use in early-stage pharmacological and toxicological evaluations.

Basic Information

Product Name	1,2,3,4,5,6-Hexahydro-3-Cyclobutylmethyl-6-Ethyl-1-Methyl-2,6-Methano-3-Benzazocin-8-Ol
CAS No.	63869-51-2
Molecular Formula	C19H27NO
Molecular Weight	285.43 g/mol
Synonyms	3-Cyclobutylmethyl-6-ethyl-1-methyl-2,6-methano-3-benzazocin-8-ol, hexahydro derivative; (-)-8-Hydroxy-3-cyclobutylmethyl-6-ethyl-1-methyl-2,6-methano-1,2,3,4,5,6-hexahydro-3-benzazocine; Potential intermediate for Tilidine analogs; 2,6-Methano-3-benzazocin-8-ol derivative; Benzazocine, hexahydro derivative; 8-Hydroxy substituted benzazocine; Cyclobutylmethyl substituted opioid scaffold
EINECS	Contact for details

Quality Control

Our 1,2,3,4,5,6-Hexahydro-3-Cyclobutylmethyl-6-Ethyl-1-Methyl-2,6-Methano-3-Benzazocin-8-Ol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D and intermediate synthesis. Certificates of Analysis (COA) detailing specifications such as assay (HPLC), chiral purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The compound may be hygroscopic; therefore, containers should be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee (by chiral HPLC)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.