Description

4,5α-Epoxy-3-Hydroxy-17-Methylmorphinan-8-One is a high-purity synthetic intermediate of significant importance in advanced pharmaceutical research and development. This compound serves as a critical precursor in the synthesis of specialized opioid receptor ligands and other pharmacologically active morphinan derivatives. It is primarily required by R&D laboratories, academic institutions, and pharmaceutical companies engaged in the development of central nervous system (CNS) targeting therapeutics and analytical method development.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel opioid analgesics and antagonists.
• Research Chemical: Used in academic and industrial research to study opioid receptor binding, structure-activity relationships (SAR), and metabolic pathways.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis using HPLC, GC-MS, or NMR.
• Preclinical Development: Employed in the early-stage development of new chemical entities (NCEs) targeting pain management and neurological disorders.
• Chemical Synthesis: Utilized in organic synthesis for the construction of complex morphinan-based molecular architectures.

Basic Information

Item	Details
Product Name	4,5α-Epoxy-3-Hydroxy-17-Methylmorphinan-8-One
CAS No.	63868-39-3
Molecular Formula	C₁₈H₂₁NO₄
Molecular Weight	315.36 g/mol
Synonyms	8-Oxo-4,5α-epoxy-3-hydroxy-17-methylmorphinan; 3-Hydroxy-17-methyl-4,5α-epoxymorphinan-8-one; 17-Methyl-4,5α-epoxy-3-hydroxymorphinan-8-one; Noroxymorphone Impurity; 8-Keto Oxymorphone; Noroxymorphone 8-Ketone; 4,5α-Epoxy-3-hydroxy-17-methylmorphinan-8-one; 8-Oxo-noroxymorphone
EINECS	Contact for details

Quality Control

Our 4,5α-Epoxy-3-Hydroxy-17-Methylmorphinan-8-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis to ensure it meets exacting standards for research and development. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.