Description

(5-Chloro-Thiophen-2-Yl)-Carbamic Acid tert-Butyl Ester is a high-purity, protected intermediate of significant value in advanced organic synthesis. This compound is critical for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique thiophene and carbamate structure serves as a versatile building block. It is primarily needed by research and development teams, process chemists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A key protected precursor in the synthesis of complex drug molecules, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity of the chlorothiophene moiety.
• Organic Synthesis Building Block: Serves as a versatile reagent for constructing heterocyclic compounds and introducing the tert-butoxycarbonyl (Boc) protecting group in multi-step synthetic routes.
• Material Science Research: Investigated as a monomer or precursor for functional polymers and advanced materials with specific electronic or optical properties.
• Contract Research & Development (CRO/CMO): Supplied to research organizations and custom manufacturers for client-specific synthesis projects and scale-up activities.

Basic Information

Product Name	(5-Chloro-Thiophen-2-Yl)-Carbamic Acid tert-Butyl Ester
CAS No.	63806-71-3
Molecular Formula	C9H12ClNO2S
Molecular Weight	233.71 g/mol
Synonyms	tert-Butyl (5-chlorothiophen-2-yl)carbamate; N-Boc-5-chloro-2-aminothiophene; 5-Chloro-2-((tert-butoxycarbonyl)amino)thiophene; 2-Amino-5-chlorothiophene N-Boc derivative; Boc-5-chloro-2-aminothiophene; (5-Chloro-2-thienyl)carbamic acid 1,1-dimethylethyl ester; 1,1-Dimethylethyl (5-chloro-2-thienyl)carbamate
EINECS	Contact for details

Quality Control

Our (5-Chloro-Thiophen-2-Yl)-Carbamic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment supports compliance with cGMP, ICH Q7 guidelines, and relevant pharmacopeial standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Purity (HPLC, Area%)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.