Description

3-Benzyloxy-4,5α-Epoxy-17-Methylmorphinan is a specialized morphinan derivative, a key synthetic intermediate in advanced pharmaceutical research and development. Its value lies in its complex, functionalized structure, which serves as a critical building block for the synthesis of novel active pharmaceutical ingredients (APIs) and reference standards. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries focused on developing new therapeutic agents, particularly within the central nervous system (CNS) and analgesic domains.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of potent opioid receptor ligands and other bioactive morphinan analogs.
• Research & Development (R&D): Used as a reference standard and a starting material in medicinal chemistry programs for structure-activity relationship (SAR) studies.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a key building block in the production route for complex, high-value APIs targeting pain management.
• Chemical Reference Standard: Employed in analytical laboratories for method development, validation, and quality control testing of related compounds.
• Process Chemistry: Utilized in scaling up synthetic pathways from laboratory to pilot plant and commercial manufacturing scales.

Basic Information

Product Name	3-Benzyloxy-4,5α-Epoxy-17-Methylmorphinan
CAS No.	63690-25-5
Molecular Formula	C25H29NO2
Molecular Weight	375.51 g/mol
Synonyms	17-Methyl-3-benzyloxy-4,5α-epoxymorphinan; 3-Benzyloxymorphinan derivative; 4,5α-Epoxy-17-methyl-3-(phenylmethoxy)morphinan; Benzyloxyepoxymethylmorphinan; O3-Benzyl-17-methyl-4,5α-epoxymorphinan
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for all our advanced intermediates. Each batch of 3-Benzyloxy-4,5α-Epoxy-17-Methylmorphinan is subjected to comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. Our quality system supports development under cGMP guidelines as required for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.