Description

1-(2-Fluorophenyl)-1H-Pyrrole-2,5-Dione is a specialized heterocyclic building block featuring a maleimide core substituted with a fluorinated aromatic ring. This compound matters as a key synthetic intermediate, offering a reactive handle for Michael additions and cycloadditions, enabling the construction of complex molecules with tailored properties. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of potential drug candidates, particularly those targeting neurological disorders or possessing kinase inhibitory activity.
• Agrochemical Research: Used in developing novel herbicides, fungicides, or insecticides where the fluorophenyl maleimide structure can impart specific bioactivity and stability.
• Material Science: Acts as a monomer or cross-linking agent in the production of advanced polymers, resins, or coatings with enhanced thermal or chemical resistance.
• Bioconjugation Chemistry: Utilized for labeling proteins, peptides, or other biomolecules due to the reactivity of the maleimide group with thiols.
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes or fluorescent tags for studying biological processes.
• Academic & Contract Research: A valuable reagent for methodological development and exploratory organic synthesis in university and CRO laboratories.

Basic Information

Product Name	1-(2-Fluorophenyl)-1H-Pyrrole-2,5-Dione
CAS No.	63566-53-0
Molecular Formula	C10H6FNO2
Molecular Weight	191.16 g/mol
Synonyms	1-(2-Fluorophenyl)-1H-pyrrole-2,5-dione; 2-Fluorophenylmaleimide; N-(2-Fluorophenyl)maleimide; 1H-Pyrrole-2,5-dione, 1-(2-fluorophenyl)-; 2-Fluoro-N-phenylmaleimide; Maleimide, N-(2-fluorophenyl)-; 63566-53-0
EINECS	Contact for details

Quality Control

Our 1-(2-Fluorophenyl)-1H-Pyrrole-2,5-Dione is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with all shipments, detailing batch-specific results. Our quality systems support development and cGMP manufacturing needs for our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.