Description

Acetic-1-13C-2-D3 Acid-1 H (D) is a stable isotope-labeled analog of acetic acid, specifically enriched with carbon-13 at the 1-position and deuterium at the 2-position, with the remaining hydrogen being protium. This compound is an essential tool for advanced analytical research, providing a non-radioactive tracer for precise metabolic pathway studies and reaction mechanism elucidation. It is primarily utilized by researchers and manufacturers in pharmaceutical development, metabolic research, and analytical chemistry for applications requiring high isotopic purity and chemical stability.

Application

• Metabolic Pathway Tracing: Used as a stable isotope tracer in in vitro and in vivo studies to track acetate utilization and acetyl-CoA metabolism.
• Pharmaceutical Research & Development: Serves as a key intermediate in the synthesis of isotopically labeled drug candidates and metabolites for pharmacokinetic and mass spectrometry studies.
• NMR Spectroscopy: Acts as a chemical shift reference and a building block for synthesizing more complex 13C- and D-labeled compounds for structural analysis.
• Mass Spectrometry (MS) Standards: Employed as an internal standard for the accurate quantification of acetic acid and related metabolites in complex biological matrices via GC-MS or LC-MS.
• Chemical Reaction Mechanism Studies: Utilized to investigate reaction kinetics and mechanisms, particularly in organic synthesis and catalysis, by following the fate of specific labeled atoms.
• Biochemical Research: Applied in enzymology studies to understand enzyme specificity and function involving acetyl group transfer.

Basic Information

Product Name	Acetic-1-13C-2-D3 Acid-1 H (D)
CAS No.	63459-47-2
Molecular Formula	C¹³CHD₃COOH
Molecular Weight	64.07 g/mol (for main isotopologue)
Synonyms	Acetic-1-13C-2,2,2-d3 Acid; [1-13C,2,2,2-2H3]Acetic Acid; (1-13C,2,2,2-D3)Acetic Acid; Deuterated Acetic-1-13C Acid; 13C,D3-Acetic Acid; Isotopic Acetic Acid; Acetic Acid (13C1, D3); Acetic-d3-1-13C Acid
EINECS	Contact for details

Quality Control

Every batch of Acetic-1-13C-2-D3 Acid-1 H (D) is produced and analyzed under strict quality management protocols. We guarantee high chemical and isotopic purity, verified by advanced analytical techniques including NMR, GC-MS, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing the isotopic enrichment, chemical purity, and solvent content. Our quality system is designed to meet the rigorous demands of research and regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area at room temperature (15-25°C). Due to its highly volatile and strong acid/organic solvent nature, keep away from heat, sparks, and open flames. Ensure containers are securely sealed to prevent evaporation and moisture absorption.

Specification

Item	Specification
Appearance	Clear, colorless liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 98.0%
Isotopic Enrichment (13C)	≥ 99 atom %
Isotopic Enrichment (D)	≥ 98 atom % (at methyl position)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.