Description

5,5-Diphenylhydantoin-D5 98 Atom % D is a high-purity, deuterium-labeled internal standard critical for modern analytical chemistry. This compound is essential for ensuring the accuracy and reliability of quantitative analyses, particularly in complex matrices. It is primarily used by researchers and quality control laboratories in the pharmaceutical, forensic, and clinical diagnostics industries for precise measurement of its non-deuterated counterpart, phenytoin.

Application

• Internal Standard for LC-MS/MS: Used as a stable isotope-labeled internal standard for the accurate quantification of phenytoin in bioanalytical methods, including pharmacokinetic and therapeutic drug monitoring studies.
• Pharmaceutical R&D: Supports drug metabolism and pharmacokinetics (DMPK) studies, enabling precise tracking of the parent drug and its metabolites in biological samples.
• Clinical Diagnostics: Enhances the precision of assays in clinical laboratories for monitoring patient serum levels of the anti-epileptic drug phenytoin.
• Forensic Toxicology: Provides a reliable reference for the confirmation and quantification of phenytoin in forensic investigations.
• Method Development & Validation: Serves as a key component in developing and validating robust, high-sensitivity analytical methods compliant with regulatory guidelines (e.g., FDA, EMA).
• Metabolite Identification: Aids in the identification and structural elucidation of phenytoin metabolites using mass spectrometry.

Basic Information

Product Name	5,5-Diphenylhydantoin-D5 98 Atom % D
CAS No.	63435-68-7
Molecular Formula	C15D5H7N2O2
Molecular Weight	257.28 g/mol
Synonyms	Phenytoin-d5; 5,5-Diphenyl-2,4-imidazolidinedione-d5; 5,5-Diphenylhydantoin-d5; Phenytoin (phenyl-d5); 2,4-Imidazolidinedione, 5,5-diphenyl-, d5; Deutetrated Phenytoin; [2H5]-Phenytoin; Dilantin-d5 (labeled analog)
EINECS	Contact for details

Quality Control

Our 5,5-Diphenylhydantoin-D5 is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for critical analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR and HPLC-MS, to confirm the 98 Atom % D isotopic enrichment and chemical identity. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and solvent content is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Isotopic Purity (Atom % D)	≥ 98%
Chemical Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.