Description

4-Chloro-3-Methylbut-1-Yne is a versatile halogenated alkyne building block of significant importance in advanced organic synthesis. Its unique structure, featuring both a reactive terminal alkyne and a chloromethyl group, makes it a critical intermediate for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in creating alkyne-linked bioactive molecules and heterocyclic compounds.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, leveraging its reactivity to introduce chloromethyl and alkyne functionalities.
• Material Science: Serves as a monomer or cross-linking agent in the development of specialty polymers and resins with tailored properties.
• Organic Synthesis Building Block: Employed in Sonogashira coupling, click chemistry (azide-alkyne cycloaddition), and other metal-catalyzed cross-coupling reactions.
• Ligand and Catalyst Development: Useful for synthesizing novel phosphine or N-heterocyclic carbene ligands containing alkyne handles for coordination chemistry.
• Chemical Research: A valuable reagent in academic and industrial R&D for exploring new synthetic methodologies and reaction pathways.

Basic Information

Item	Details
Product Name	4-Chloro-3-Methylbut-1-Yne
CAS No.	63150-17-4
Molecular Formula	C5H7Cl
Molecular Weight	102.56 g/mol
Synonyms	3-Methyl-4-chloro-1-butyne; 4-Chloro-3-methyl-1-butyne; 1-Butyne, 4-chloro-3-methyl-; 4-Chloro-3-methylbutyne; (Chloromethyl)isopropylacetylene; 3-Methylbut-1-yn-4-yl chloride
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-Methylbut-1-Yne is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including chromatography (GC/HPLC) and spectroscopic methods (NMR, IR), to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to guarantee compliance with your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, open flames, and strong oxidizing agents. Due to the reactive alkyne and chloro functionalities, it is recommended to store under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.