Description

tert-Butyl [R-(R*,S*)]-[1-[[(2,5-Dioxopyrrolidin-1-yl)oxy]carbonyl]-2-hydroxypropyl]carbamate is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is critical for researchers and manufacturers requiring precise chiral building blocks with protected functional groups for peptide and small-molecule drug development. It is primarily utilized in the pharmaceutical, biotechnology, and advanced chemical synthesis sectors where stringent quality and reliable supply are paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel therapeutic agents, particularly in oncology and metabolic disease research.
• Peptide Chemistry: Serves as a protected amino acid derivative for solid-phase and solution-phase peptide synthesis, enabling the construction of complex peptide sequences.
• Prodrug Development: Used in the design and synthesis of prodrugs, where its active ester (NHS ester) moiety facilitates targeted drug delivery and release mechanisms.
• Bioconjugation: The N-hydroxysuccinimide (NHS) ester group allows for efficient conjugation of drug molecules to antibodies, proteins, or other biological carriers.
• Chemical Biology Research: Employed as a tool compound for labeling and studying biological pathways and protein interactions.
• Process Chemistry & Scale-Up: Suitable for process development and optimization from laboratory to pilot plant scale, supporting cGMP manufacturing.

Basic Information

Product Name	tert-Butyl [R-(R*,S*)]-[1-[[(2,5-Dioxopyrrolidin-1-yl)oxy]carbonyl]-2-hydroxypropyl]carbamate
CAS No.	63076-44-8
Molecular Formula	C13H20N2O7
Molecular Weight	316.31 g/mol
Synonyms	Boc-Thr(OSu)-OH; N-Boc-O-(N-succinimidyl)-L-threonine; N-(tert-Butoxycarbonyl)-O-(N-succinimidyl)-L-threonine; tert-Butyl (2S,3R)-3-hydroxy-1-[(2,5-dioxopyrrolidin-1-yl)oxy]-1-oxobutan-2-ylcarbamate; Boc-L-threonine N-hydroxysuccinimide ester; Boc-Thr-OSu; (2S,3R)-2-[(tert-Butoxycarbonyl)amino]-3-hydroxybutanoic acid 2,5-dioxopyrrolidin-1-yl ester
EINECS	Contact for details

Quality Control

Our production of tert-Butyl [R-(R*,S*)]-[1-[[(2,5-Dioxopyrrolidin-1-yl)oxy]carbonyl]-2-hydroxypropyl]carbamate adheres to rigorous quality systems suitable for pharmaceutical development. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specific results for chiral purity, assay, and related substances are provided and can be tailored to meet client-specific monograph requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% de
Water Content (KF)	≤0.5%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Impurity	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.