Description

1,2,3,4-Tetrahydroisoquinoline-3-Methanol is a versatile heterocyclic building block and chiral intermediate of significant interest in advanced organic synthesis. Its unique fused-ring structure containing both a tetrahydroisoquinoline core and a hydroxymethyl group makes it a valuable precursor for constructing complex pharmacologically active molecules. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly within the fields of central nervous system (CNS) drug discovery and alkaloid chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of potential drug candidates, including enzyme inhibitors and receptor modulators.
• Alkaloid Synthesis: Serves as a fundamental scaffold in the preparation of complex tetrahydroisoquinoline alkaloids and their analogs for biological evaluation.
• Asymmetric Catalysis Research: Used as a ligand precursor or a chiral pool starting material in the development of new catalytic systems.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore new chemical spaces for therapeutic applications.
• Fine Chemical Production: Utilized in the multi-step synthesis of specialty chemicals and high-value agrochemical intermediates.
• Academic Research: A valuable compound for methodological studies in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	1,2,3,4-Tetrahydroisoquinoline-3-Methanol
CAS No.	63006-93-9
Molecular Formula	C₁₁H₁₅NO
Molecular Weight	177.24 g/mol
Synonyms	1,2,3,4-Tetrahydro-3-isoquinolinemethanol; (1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol; 3-(Hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline; THIQ-3-Methanol; 3-Hydroxymethyl-1,2,3,4-tetrahydroisoquinoline; 1,2,3,4-Tetrahydro-3-isoquinolinecarbinol; 3-Methanol-1,2,3,4-tetrahydroisoquinoline
EINECS	Contact for details

Quality Control

Our 1,2,3,4-Tetrahydroisoquinoline-3-Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.