Description

n-Nitrosobenzylmethyl-D3-Amine is a stable isotope-labeled (deuterated) nitrosamine compound, specifically designed for use as an analytical standard and reference material. This high-purity compound is critical for ensuring accurate quantification and trace analysis in complex matrices, addressing the need for reliable internal standards in mass spectrometry. It is primarily utilized by analytical laboratories, research institutions, and quality control departments in the pharmaceutical, food safety, and environmental monitoring sectors to detect and quantify nitrosamine impurities, which are potent carcinogens of significant regulatory concern.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard for the precise quantification of benzylmethylnitrosamine and related nitrosamine impurities in pharmaceutical drug substances and products (e.g., Sartans, Metformin, Ranitidine).
• Food and Beverage Safety Testing: Employed in analytical methods to monitor and quantify nitrosamine levels in processed foods, cured meats, and alcoholic beverages to ensure compliance with food safety regulations.
• Environmental Analysis: Applied in the trace analysis of nitrosamine contaminants in water supplies, wastewater, and soil samples.
• Metabolic and Toxicological Research: Serves as a stable isotope-labeled tracer in studies investigating the metabolism, distribution, and carcinogenic mechanisms of nitrosamines.
• Method Development and Validation: Essential reference material for developing, optimizing, and validating sensitive and selective analytical methods (HPLC, GC-MS) for nitrosamine detection.
• Quality Control and Assurance: Provides a benchmark for calibrating equipment and verifying the accuracy of testing protocols within quality control laboratories.

Basic Information

Product Name	n-Nitrosobenzylmethyl-D3-Amine
CAS No.	62845-80-1
Molecular Formula	C8H6D3N2O
Molecular Weight	152.19 g/mol
Synonyms	Benzylmethylnitrosamine-d3; N-Nitroso-N-methylbenzylamine-d3; N-Methyl-N-nitrosobenzenemethanamine-d3; N-Nitroso-N-methylbenzyl-d3-amine; N-Benzyl-N-methylnitrosamine-d3; Deutero-n-nitrosobenzylmethylamine; MBNA-d3; BMNA-d3
EINECS	Contact for details

Quality Control

Every batch of n-Nitrosobenzylmethyl-D3-Amine is manufactured and analyzed under strict quality management protocols. We provide comprehensive Certificates of Analysis (COA) that detail critical parameters including isotopic purity, chemical purity, and identity confirmation. Our products are suitable for use as certified reference materials (CRMs) and are developed in compliance with relevant guidelines for analytical standards. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Keep away from heat and open flame. For long-term storage, consider storing under inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	Yellow to orange liquid or oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content, MS)	≥ 98.0 atom % D
Chemical Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.