Description

1-(5-Bromo-Thiophen-2-Yl)-2-Chloro-Ethanone is a high-purity halogenated thiophene derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its bifunctional reactivity, where the bromo and chloro substituents offer distinct, orthogonal sites for selective cross-coupling and nucleophilic substitution reactions. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and complex heterocyclic molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting the central nervous system and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the thiophene scaffold for bioactivity.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of conductive polymers and organic semiconductors.
• Organic Synthesis Building Block: Employed in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) and as an electrophile in nucleophilic aromatic substitution to construct complex molecular architectures.
• Ligand and Catalyst Development: Utilized for synthesizing specialized ligands for metal complexes used in homogeneous catalysis.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D labs exploring new synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	1-(5-Bromo-Thiophen-2-Yl)-2-Chloro-Ethanone
CAS No.	62673-67-0
Molecular Formula	C6H4BrClOS
Molecular Weight	239.52 g/mol
Synonyms	2-Chloro-1-(5-bromothiophen-2-yl)ethanone; 5-Bromo-2-chloroacetylthiophene; 2-Chloro-1-(5-bromo-2-thienyl)ethanone; 1-(5-Bromo-2-thienyl)-2-chloroethanone; 2-Acetyl-5-bromothiophene, 2'-chloro derivative; 5-Bromo-2-thienyl chloromethyl ketone; (5-Bromo-2-thienyl)chloromethyl ketone; α-Chloro-5-bromo-2-acetylthiophene
EINECS	Contact for details

Quality Control

Our production of 1-(5-Bromo-Thiophen-2-Yl)-2-Chloro-Ethanone adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analysis, including HPLC for purity, NMR for structural confirmation, and GC for residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical parameters to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.