Description

L-Tyrosine-2,3,5,6-D4 is a stable isotope-labeled analog of the essential amino acid L-Tyrosine, specifically deuterated at the 2, 3, 5, and 6 positions of the aromatic ring. This high-purity compound is critical for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical measurements. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, biotechnology, and clinical diagnostics industries for advanced metabolic studies, proteomics, and pharmacokinetic research.

Application

• Quantitative Mass Spectrometry (MS): Serves as a crucial internal standard for the precise quantification of endogenous L-Tyrosine and related metabolites in complex biological matrices like plasma, urine, and tissue homogenates.
• Metabolomics & Metabolic Pathway Analysis: Enables accurate tracing and flux analysis in studies of phenylalanine and tyrosine metabolism, catecholamine biosynthesis, and related disorders.
• Pharmaceutical Drug Development & PK/PD Studies: Used in pharmacokinetic (PK) and pharmacodynamic (PD) studies to monitor drug metabolism and biomarker levels with high specificity and reduced matrix effects.
• Clinical Diagnostics & Research: Facilitates the development and validation of diagnostic assays for conditions such as tyrosinemia, Parkinson's disease, and other metabolic or neurological disorders.
• Proteomics & Protein Turnover Studies: Employed in stable isotope labeling techniques (SILAC, etc.) to study protein synthesis, degradation, and post-translational modifications.
• Nutritional Science Research: Used to investigate amino acid absorption, bioavailability, and metabolism in nutritional studies and dietary intervention research.

Basic Information

Item	Detail
Product Name	L-Tyrosine-2,3,5,6-D4
CAS No.	62595-14-6
Molecular Formula	C9H7D4NO3
Molecular Weight	185.21 g/mol
Synonyms	(2S)-2-Amino-3-(2,3,5,6-tetradeuterio-4-hydroxyphenyl)propanoic acid; L-Tyrosine-d4; Tyrosine-2,3,5,6-d4; (S)-Tyrosine-2,3,5,6-d4; 4-Hydroxyphenyl-d4-alanine; 3-(4-Hydroxyphenyl-2,3,5,6-d4)-L-alanine; L-Tyrosine (phenyl-2,3,5,6-d4); L-Tyrosine (ring-2,3,5,6-d4)
EINECS	Contact for details

Quality Control

Our L-Tyrosine-2,3,5,6-D4 is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (atom % D), chemical purity (by HPLC), and specific optical rotation. We adhere to relevant industry standards for high-purity reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or CoA. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Optical Rotation	-10.0° to -12.0° (c=1 in 1N HCl)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.